Ginger - Get the Facts on Herbal Supplements

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  • There is mixed evidence in this area, with some studies reporting that ginger has no effect on motion sickness, and other research noting that ginger may reduce vomiting (but not nausea).<a href="#hdng0">(More...)</a>

  • CDPH and the U.S. Food and Drug Administration are tracing the imported ginger from the importer (Modern Trading Inc. in Alhambra, California) to determine the full distribution of the product and to identify other retail stores that may have received the product.<a href="#hdng1">(More...)</a>



<a name="hdng0"></a>There is mixed evidence in this area, with some studies reporting that ginger has no effect on motion sickness, and other research noting that ginger may reduce vomiting (but not nausea). Before a recommendation can be made, more studies are needed comparing ginger to other drugs used for this purpose. <a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Early studies suggest that ginger may be safe and effective for nausea and vomiting of pregnancy when used at recommended doses for short periods of time.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Some human studies report improvement in nausea or vomiting after surgery if patients take ginger before surgery. Other research shows no difference.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Initial human research reports that ginger may reduce the severity and length of time that cancer patients feel nauseous after chemotherapy. Other studies show no effects. Additional studies are needed to confirm these results and to determine safety and dosing.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Ginger has been studied as a possible treatment for osteoarthritis. Results of these studies are mixed. More research is needed in this area.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a>

Additional studies are needed before the use of ginger before surgery to help with nausea and vomiting can be recommended.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Bryer E. A literature review of the effectiveness of ginger in alleviating mild-to-moderate nausea and vomiting of pregnancy.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Vutyavanich T, Kraisarin T, Ruangsri R. Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> In theory, ginger with large amounts of calcium may increase the risk of abnormal heart rhythms. Study results suggest that dietary phytochemicals, such as capsaicin, curcumin, and resveratrol, have inhibitory effects on P-glycoprotein and potencies to cause drug-food interactions.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> In theory, ginger may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding (although clear human evidence is lacking).<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> In theory, ginger may increase the risk of bleeding when taken with blood-thinners (although clear human evidence is lacking). Some examples include aspirin, anticoagulants such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a>

There is evidence that ginger may increase stomach acid production. It theoretically may work against the effects of antacids, sucralfate (Carafate®), or anti-reflux medications such as H-2 blockers like ranitidine (Zantac®) or proton pump inhibitors like lansoprazole (Prevacid®). Other laboratory and animal studies report that ginger may act to protect the stomach.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Because ginger can theoretically lower blood sugar levels, it may interfere with the effects of insulin or diabetes medications that are taken by mouth.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> In theory, large doses of ginger may increase the effects of medications that slow thinking or cause drowsiness.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> One study suggested that ginger may have a synergistic effect on anti-platelet aggregation in patients with high blood pressure when used in combination with nifedipine. More study is warranted in this area.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Ginger may also interact with herbs or supplements taken for nausea/vomiting, pain, arthritis, blood disorders, high cholesterol, high/low blood pressure, allergies (antihistamines), cancer, inflammation, vasodilators, or weight loss.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Ginger may interact with herbs broken down by the liver or with xanthine oxidase herbs.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Ginger may interact with drugs broken down by the liver or with xanthine oxidase drugs.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Caution is advised when taking ginger with drugs that weaken the immune system, due to a possible interaction.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a>

Borrelli F, Capasso R, Aviello G, et al. Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Eberhart LH, Mayer R, Betz O, et al. Ginger does not prevent postoperative nausea and vomiting after laparoscopic surgery.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Visalyaputra S, Petchpaisit N, Somcharoen K, et al. The efficacy of ginger root in the prevention of postoperative nausea and vomiting after outpatient gynaecological laparoscopy.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Chaiyakunapruk N, Kitikannakorn N, Nathisuwan S, et al. The efficacy of ginger for the prevention of postoperative nausea and vomiting: a meta-analysis.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a>

Ginger may have antioxidant properties and use with other antioxidants may result in additive effects.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> The use of ginger in pregnancy is cautioned against in traditional Chinese medicine (TCM).<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Additional research is needed to determine the safety and effectiveness of ginger during pregnancy before it can be recommended for longer periods of time.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Some publications discourage large doses of ginger during pregnancy due to concerns about mutations or abortions.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Many experts and publications suggest that ginger powder, tablets, or capsules or freshly cut ginger can be used in doses of 1 to 5 grams daily, by mouth, divided into smaller doses.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Many publications note that the maximum recommended daily dose of ginger is 4 grams. It is believed that the mild stomach upset sometimes caused by ginger may be reduced by taking ginger capsules rather than powder.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Ginger is traditionally said to reduce blood sugar levels at high doses, but there is a lack of scientific evidence available.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Ginger is used orally, topically, and intramuscularly for a wide array of other conditions, without scientific evidence of benefit.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> There is insufficient scientific evidence to recommend the use of ginger in children.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> There is limited scientific evidence in this area, and it is not clear if ginger is beneficial.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a>

There is supportive evidence from one randomized controlled trial and an open-label study that ginger reduces the severity and duration of chemotherapy-induced nausea/emesis.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Ginger has been suggested as a possible weight loss aid, but more study is needed to a make a firm recommendation.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> In one study, two of eight participants reported an intense urge to urinate 30 minutes after ingesting ginger. Ginger has also been associated with pinkeye (conjunctivitis), but this was considered a rare occurrence.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Irritation or bad taste in the mouth, heartburn, belching, bloating, gas, and nausea have been reported, especially with powdered forms of ginger.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> The most commonly reported side effects of ginger involve the stomach and intestines.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a>

Caution is advised when taking ginger with herbs or supplements that affect the immune system, due to possible interactions.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Common forms of ginger include fresh root, dried root, tablets, capsules, liquid extract, tincture, and tea.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a>

In theory, ginger can cause abnormal heart rhythms, although reports in humans are lacking.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> There are several reports that fresh ginger that is swallowed without enough chewing can result in blockage of the intestines.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a>

Ginger may inhibit platelet aggregation/decrease platelet thromboxane production, thus theoretically increasing bleeding risk.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Ginger may theoretically prevent blood clotting by preventing the clumping of platelets. In one study, gingerol compounds and their derivatives were shown to be more potent anti-platelet agents than aspirin. This raises a concern that individuals who are treated with medications that slow blood clotting or who undergo surgery may have a high risk of excessive bleeding if they take ginger supplements.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a>

Ginger may also interfere with medications that change the contraction of the heart, including beta-blockers, digoxin, and other heart medications.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Some publications suggest that ginger may raise or lower blood pressure, although limited scientific information is available.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Some authors suggest that pregnant women should not take ginger in amounts greater than found in food (or more than 1 gram dry weight per day).<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a>

It is unclear if ginger can help treat urinary disorders in patients recovering from strokes.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Wigler I, Grotto I, Caspi D, et al. The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a>

Bliddal H, Rosetzsky A, Schlichting P, et al. A randomized, placebo-controlled, cross-over study of ginger extracts and ibuprofen in osteoarthritis.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a>

There is a lack of available studies that confirm the long-term, safe use of ginger supplements.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a> Individuals who have had ulcers, inflammatory bowel disease, or blocked intestines should use ginger supplements cautiously and should avoid large amounts of freshly cut ginger.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a>

The optimal dose remains unclear. Ginger's effects on other types of nausea/emesis, such as postoperative nausea or motion sickness, remain indeterminate.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank" [1]</a>

The general safety and effectiveness of ginger's use for health purposes, as well as its active components and effects on inflammation.<a href="http://nccam.nih.gov/health/ginger/" TARGET="_blank" [2]</a> Studies suggest that the short-term use of ginger can safely relieve pregnancy-related nausea and vomiting.<a href="http://nccam.nih.gov/health/ginger/" TARGET="_blank" [2]</a> Studies are mixed on whether ginger is effective for nausea caused by motion, chemotherapy, or surgery. It is unclear whether ginger is effective in treating rheumatoid arthritis, osteoarthritis, or joint and muscle pain. Whether ginger interacts with drugs, such as those used to suppress the immune system.<a href="http://nccam.nih.gov/health/ginger/" TARGET="_blank" [2]</a> Ginger is used to alleviate postsurgery nausea as well as nausea caused by motion, chemotherapy, and pregnancy.<a href="http://nccam.nih.gov/health/ginger/" TARGET="_blank" [2]</a> Ginger is used in Asian medicine to treat stomach aches, nausea, and diarrhea.<a href="http://nccam.nih.gov/health/ginger/" TARGET="_blank" [2]</a>

Side effects most often reported are gas, bloating, heartburn, and nausea. These effects are most often associated with powdered ginger.<a href="http://nccam.nih.gov/health/ginger/" TARGET="_blank" [2]</a>

Tell your health care providers about any herb or dietary supplement A product that contains vitamins, minerals, herbs or other botanicals, amino acids, enzymes, and/or other ingredients intended to supplement the diet. The U.S. Food and Drug Administration has special labeling requirements for dietary supplements and treats them as foods, not drugs. you are using, including ginger. This helps to ensure safe and coordinated care.<a href="http://nccam.nih.gov/health/ginger/" TARGET="_blank" [2]</a> The underground stems of the ginger plant are used in cooking, baking, and for health purposes.<a href="http://nccam.nih.gov/health/ginger/" TARGET="_blank" [2]</a> Ginger has been used for rheumatoid arthritis, osteoarthritis, and joint and muscle pain.<a href="http://nccam.nih.gov/health/ginger/" TARGET="_blank" [2]</a> Ginger is a tropical plant that has green-purple flowers and an aromatic underground stem (called a rhizome). It is commonly used for cooking and medicinal purposes.<a href="http://nccam.nih.gov/health/ginger/" TARGET="_blank" [2]</a>

Common forms of ginger include fresh or dried root, tablets, capsules, liquid extracts (tinctures), and teas.<a href="http://nccam.nih.gov/health/ginger/" TARGET="_blank" [2]</a>

Many digestive, antinausea, and cold and flu dietary supplements sold in the United States contain ginger extract as an ingredient.<a href="http://nccam.nih.gov/health/ginger/" TARGET="_blank" [2]</a>

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<a name="hdng1"></a>CDPH and the U.S. Food and Drug Administration are tracing the imported ginger from the importer (Modern Trading Inc. in Alhambra, California) to determine the full distribution of the product and to identify other retail stores that may have received the product. <a href="http://www.fda.gov/oc/po/firmrecalls/cdph207_07.html" TARGET="_blank" [3]</a> Currently, there are no reports of illness associated with the contaminated ginger. Consumers who may have purchased this product from Albertson's stores and Save Mart stores in northern California should discard it.<a href="http://www.fda.gov/oc/po/firmrecalls/cdph207_07.html" TARGET="_blank" [3]</a>

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1. <a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank">MedlinePlus Herbs and Supplements: Ginger (Zingiber officinale Roscoe)</a>
<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html" TARGET="_blank">http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-ginger.html</a>

2. <a href="http://nccam.nih.gov/health/ginger/" TARGET="_blank">Ginger - Zingiber officinale [NCCAM Herbs at a Glance]</a>
<a href="http://nccam.nih.gov/health/ginger/" TARGET="_blank">http://nccam.nih.gov/health/ginger/</a>

3. <a href="http://www.fda.gov/oc/po/firmrecalls/cdph207_07.html" TARGET="_blank">California Department of Public Health Warns Consumers Not to Eat Fresh Ginger From China</a>
<a href="http://www.fda.gov/oc/po/firmrecalls/cdph207_07.html" TARGET="_blank">http://www.fda.gov/oc/po/firmrecalls/cdph207_07.html</a>

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